Tytuł:

Expression of estrogen and progesterone receptors in melanocytic neviand melanomas

Autor:

Spałkowska, Magdalena

Temat i słowa kluczowe:

nevus ; progesterone ; estrogens ; melanoma

Abstrakt:

In the first part of the study we assessed the expression of estrogen (α,β, GPER) and progesterone receptors in common nevi, dysplastic nevi, melanomas and healthy skin tissue margin. In the second part of the study we evaluated GPER expression in melanomas and margin tissue in men and women of different hormonal status. We have shown the presence of significant differences in estrogen β expressionin margin melanocytes between common and dysplastic nevi. Keratinocytes of melanomas and dysplastic nevi differed in estrogen receptor β expression. We did not show significant differences in estrogen α and β in relation to known prognostic factors in melanoma. Significant differences were found in estrogen β and GPER expression between margin and melanoma melanocytes. Melanocytes of melanomas and dysplastic nevi differed in GPER expression. There was a positive correlation between nuclear and cytoplasmic GPER expression in melanoma melanocytes and Clark and Breslow scales. There were differences in GPER expression in melanocytes concerning the presence of ulceration, mitotic figures and growth phase.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

dermatologia

Instytucja nadająca tytuł:

Rada Dyscypliny Nauki medyczne

Promotor:

Wojas-Pelc, Anna

Data:

2020

Data wydania:

2019

Typ:

Praca doktorska

Sygnatura:

ZB-132292

Język:

pol

Prawa dostępu:

nieograniczony